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Empowering Practitioners: Unlocking Potential in Posterior Cortical Atrophy Diagnosis

Empowering Practitioners: Unlocking Potential in Posterior Cortical Atrophy Diagnosis

Understanding Posterior Cortical Atrophy: A Call to Action for Practitioners

Posterior Cortical Atrophy (PCA) is a rare neurodegenerative syndrome often linked to Alzheimer's Disease (AD). It is characterized by a decline in higher-order visuospatial and visuoperceptual functions. As practitioners, understanding the nuances of PCA can significantly enhance our ability to provide timely and accurate diagnoses, which is crucial given the syndrome's tendency for delayed diagnosis and frequent misdiagnosis as ocular or psychological conditions.

Key Findings from Recent Research

Recent multi-center consensus recommendations have provided new criteria for PCA, emphasizing the predominance of primary or co-existing AD pathology. The research highlights that PCA diagnosis is frequently delayed, with patients often receiving misdiagnoses. The study underscores the importance of interdisciplinary management tailored to the PCA clinical profile, which is visual-spatial rather than memory-led, and predominantly young onset.

Improving Diagnostic Accuracy

Practitioners can improve diagnostic accuracy by incorporating comprehensive neurological and neuropsychological assessments, supported by structural brain imaging. MRI scans typically reveal posterior atrophy, which can be further evaluated using FDG-PET or SPECT imaging to establish posterior-predominant neuronal injury. Additionally, the use of biomarkers is crucial in establishing a neurodegenerative basis and determining underlying pathology.

Management Strategies

Management of PCA should be individualized, focusing on both pharmacological and non-pharmacological approaches. While pharmacological treatments for PCA-AD are limited, they can be informed by treatments for typical AD. Non-pharmacological management involves interdisciplinary care, including support from ophthalmologists, neurologists, and social care professionals. Tailored strategies to manage visual perception, spatial awareness, and mobility are essential.

Encouraging Further Research

Despite advancements, there are still significant knowledge gaps in PCA, particularly concerning the suitability of PCA participants for conventional clinical trials and the potential differing treatment responses. Practitioners are encouraged to engage in further research to explore these areas, which could lead to more effective management strategies and improved patient outcomes.

To read the original research paper, please follow this link: Diagnosis and Management of Posterior Cortical Atrophy.


Citation: Yong, K. X. X., Graff-Radford, J., Ahmed, S., Chapleau, M., Ossenkoppele, R., Putcha, D., Rabinovici, G. D., Suarez-Gonzalez, A., Schott, J. M., Crutch, S., & Harding, E. (2023). Diagnosis and management of posterior cortical atrophy. Current Treatment Options in Neurology, 25(2), 23-43. https://doi.org/10.1007/s11940-022-00745-0
Marnee Brick, President, TinyEYE Therapy Services

Author's Note: Marnee Brick, TinyEYE President, and her team collaborate to create our blogs. They share their insights and expertise in the field of Speech-Language Pathology, Online Therapy Services and Academic Research.

Connect with Marnee on LinkedIn to stay updated on the latest in Speech-Language Pathology and Online Therapy Services.

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