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Improving Recognition and Management of Non-IgE-Mediated Cow’s Milk Allergy in Infancy

Improving Recognition and Management of Non-IgE-Mediated Cow’s Milk Allergy in Infancy

Cow’s milk allergy (CMA) is a prevalent concern in early childhood, with a significant number of cases presenting as non-IgE-mediated allergies. These types of allergies often manifest with delayed gastrointestinal symptoms, making them challenging to diagnose and manage effectively. The iMAP guideline offers an international perspective on the Milk Allergy in Primary Care (MAP) guideline, providing a framework for practitioners worldwide to better recognize and manage these conditions.

The Need for Improved Diagnosis

The complexity of CMA stems from its varied presentations, which can be broadly categorized into IgE-mediated and non-IgE-mediated forms. Non-IgE-mediated CMA often presents with symptoms such as abdominal discomfort, gastro-oesophageal reflux, and abnormal bowel movements. These symptoms can overlap with common infant health issues, leading to potential misdiagnosis or delayed diagnosis.

The iMAP guideline emphasizes the importance of an allergy-focused clinical history. Practitioners should inquire about family history of atopic diseases, early atopic manifestations in the infant, feeding history, growth patterns, and any previous management attempts. This comprehensive approach helps differentiate between IgE-mediated and non-IgE-mediated reactions.

Implementing the iMAP Guideline

The iMAP guideline recommends a trial elimination diet followed by reintroduction to confirm a diagnosis of non-IgE-mediated CMA. This process involves removing all cow’s milk products from the diet for a specified period, monitoring symptom improvement, and then reintroducing the allergen to observe any recurrence of symptoms.

This method ensures that infants are not unnecessarily kept on restrictive diets without proper confirmation of an allergy.

Management Strategies in Primary Care

The iMAP guideline provides a structured approach for ongoing management within primary care settings. It emphasizes the role of dietetic support in ensuring nutritional adequacy and guiding families through the process of milk-free weaning and subsequent dietary reintroduction.

The Role of Healthcare Professionals

The iMAP guideline underscores the importance of collaboration between healthcare professionals and families. Practitioners are encouraged to involve family members in decision-making processes regarding investigations and treatment plans. This collaborative approach not only empowers families but also facilitates better health outcomes for infants with CMA.

The Global Impact of iMAP

The international adoption of the iMAP guideline highlights its relevance across different healthcare systems. By providing practical tools such as algorithms and symptom checklists, it aids practitioners worldwide in improving recognition and management of non-IgE-mediated CMA.

This global perspective ensures that infants receive timely and accurate diagnoses, reducing unnecessary dietary restrictions and improving quality of life for affected families.

Better recognition, diagnosis and management of non-IgE-mediated cow’s milk allergy in infancy: iMAP—an international interpretation of the MAP (Milk Allergy in Primary Care) guideline


Citation: CITATION: Venter, C., Brown, T., Meyer, R., Walsh, J., Shah, N., Nowak-Wegrzyn, A., Chen, T.-X., Fleischer, D. M., Heine, R. G., Levin, M., Vieira, M. C., & Fox, A. T. (2017). Better recognition, diagnosis and management of non-IgE-mediated cow’s milk allergy in infancy: iMAP—an international interpretation of the MAP (Milk Allergy in Primary Care) guideline. Clinical & Translational Allergy, 7(1), 26-28.
Marnee Brick, President, TinyEYE Therapy Services

Author's Note: Marnee Brick, TinyEYE President, and her team collaborate to create our blogs. They share their insights and expertise in the field of Speech-Language Pathology, Online Therapy Services and Academic Research.

Connect with Marnee on LinkedIn to stay updated on the latest in Speech-Language Pathology and Online Therapy Services.

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