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Understanding Dyslexia: The Role of Neural Variability and Genetics

Understanding Dyslexia: The Role of Neural Variability and Genetics

Dyslexia is a complex reading disorder that affects many children worldwide. Despite average intelligence and adequate schooling, children with dyslexia struggle with reading and language processing. Recent research has begun to unravel the intricate relationship between genetic factors and neural responses that contribute to this condition. A study titled "Increased variability of stimulus-driven cortical responses is associated with genetic variability in children with and without dyslexia" sheds light on these connections.

The Study: Key Findings

The research conducted by Centanni et al. (2018) explored the variability in neural responses among children with and without dyslexia using magnetoencephalography (MEG). The study found that approximately half of the children with dyslexia exhibited significantly higher levels of neural variability in response to auditory and visual stimuli compared to their typically developing peers. This increased variability was particularly notable in the primary auditory cortex and other regions associated with reading.

Genetic Links

A significant finding from the study is the association between the gene KIAA0319 and neural variability. The presence of specific risk alleles in this gene was linked to greater neural response variability in the auditory cortex. This suggests that genetic factors may contribute to the unstable neural representations observed in some children with dyslexia.

Implications for Practitioners

Understanding the role of neural variability and genetic factors in dyslexia can significantly impact educational strategies and interventions. Here are some ways practitioners can apply these insights:

Encouraging Further Research

The findings from this study open up several avenues for further research. Understanding how different genetic factors interact with environmental influences could provide deeper insights into dyslexia's underlying mechanisms. Additionally, exploring how increased neural variability affects other cognitive functions could lead to more comprehensive support strategies for affected individuals.

For practitioners interested in delving deeper into this topic, further exploration into how these findings can be integrated into practical applications is encouraged. Collaboration between researchers, educators, and clinicians will be essential in developing innovative solutions to support children with dyslexia.

To read the original research paper, please follow this link: Increased variability of stimulus-driven cortical responses is associated with genetic variability in children with and without dyslexia.


Citation: Centanni, T.M., Pantazis, D., Truong, D.T., Gruen, J.R., Gabrieli, J.D.E., & Hogan, T.P. (2018). Increased variability of stimulus-driven cortical responses is associated with genetic variability in children with and without dyslexia. Developmental Cognitive Neuroscience, 34(7), 17-34. https://doi.org/10.1016/j.dcn.2018.05.008
Marnee Brick, President, TinyEYE Therapy Services

Author's Note: Marnee Brick, TinyEYE President, and her team collaborate to create our blogs. They share their insights and expertise in the field of Speech-Language Pathology, Online Therapy Services and Academic Research.

Connect with Marnee on LinkedIn to stay updated on the latest in Speech-Language Pathology and Online Therapy Services.

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