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Differential Vulnerability of the Dentate Gyrus to Tauopathies in Dementias: Implications for Practitioners

Differential Vulnerability of the Dentate Gyrus to Tauopathies in Dementias: Implications for Practitioners

Introduction

Understanding the differential vulnerability of brain regions to tauopathies is crucial for improving therapeutic strategies in dementia care. The research article "Differential vulnerability of the dentate gyrus to tauopathies in dementias" sheds light on how the dentate gyrus (DG), a key hippocampal subregion, is affected by various tauopathies. This blog will explore the study's findings and discuss their implications for practitioners working with dementia patients, particularly those with primary progressive aphasia (PPA).

Key Findings

The study analyzed 32 brains with autopsy-confirmed tauopathies, focusing on the DG's susceptibility to tau inclusions. It found that:

Implications for Practitioners

These findings have several implications for practitioners:

Encouraging Further Research

The study raises intriguing questions about the structural integrity and functional significance of hippocampal circuits in neurodegenerative dementias. Practitioners are encouraged to engage in further research to explore these questions, particularly focusing on:

To read the original research paper, please follow this link: Differential vulnerability of the dentate gyrus to tauopathies in dementias.


Citation: Kawles, A., Minogue, G., Zouridakis, A., Keszycki, R., Gill, N., Nassif, C., Coventry, C., Zhang, H., Rogalski, E., Flanagan, M. E., Castellani, R., Bigio, E. H., Mesulam, M. M., & Geula, C. (2023). Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta Neuropathologica Communications, 11, 1-21. https://doi.org/10.1186/s40478-022-01485-7
Marnee Brick, President, TinyEYE Therapy Services

Author's Note: Marnee Brick, TinyEYE President, and her team collaborate to create our blogs. They share their insights and expertise in the field of Speech-Language Pathology, Online Therapy Services and Academic Research.

Connect with Marnee on LinkedIn to stay updated on the latest in Speech-Language Pathology and Online Therapy Services.

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